Endocrine Abstracts

Introduction: Copeptin can be used as a tool to directly assess serum antidiuretic hormone (ADH) level. A certain pool of ADH are synthesized in hypothalamus, together with corticoliberin (CRH). Then they are released into the pituitary portal circulation, where through the V1bR receptor ADH stimulates adrenocorticotropic cells and ACTH secretion, followed by cortisol and catecholamines production. The stimulus for ADH secretion is, among others, stress. In turn, presynaptic s...